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1. We should know the women's LMP, breast cancer type and diagnosed time, detailed treatment history (radiation?).
2. If this patient is not in LMP or within 12 days, At most I may consider to call AGC based on the first photo. The AGC may represent neoplastic lesions or reactive change, especially for this women with history of chemotherapy, 带环 (the patient has or not???).
3. Remember that most women (70-80%) with AGC Pap would have no neoplastic lesions. Again Pap test is a screening test. You must be 100% sure, otherwise please do not call malignant for your pap test, especially for this 35 young lady.
4. if the women is in LMP or within 12 days, we need to think over the meaning of these cells.
5. Breast cancer cells can occour in the Pap smear, but it is very rare.
6. Also we should consider the patient's age. If the young women has both breast and gynecologic tumor, the patient may have BRCA gene mutation.
just for your reference.
我来帮赵老师翻译一下:
1。我们应该知道病人的末次月经,乳腺癌的类型、诊断时间和具体的治疗方案(是否用过放疗)?
2。如果这个病人不是在末次月经或者12天之内,根据第一张图我最多认为是非典型腺细胞。AGC可能代表肿瘤性的或者反应性病变,特别是在这样一个化疗史或者带环(? ? ?)患者
3。应当记住的是细胞学报AGC的病人70-80%是没有病变的,除非你是100%的确定,否则在细胞学上不要报恶性,特别是这个病人仅35岁
4如果这个病人是在末次月经或者12天之内,我们需要仔细考虑这些细胞的意义
5 乳腺癌细胞可以出现在巴氏涂片中,但是非常罕见。
6 我们也应该考虑患者的年龄。如果是年轻女性既有乳腺癌又有妇科肿瘤,病人可能有BRCA基因突变。
仅供参考。
乳腺癌术后经Tamoxifen治疗后,极有可能发生子宫癌。请见文献报道。
1: Br J Cancer. 2008 Mar 11;98(5):870-4. Epub 2008 Feb 12.